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Diazepam

From Wikipedia, the free encyclopedia

Diazepam chemical structure
7-chloro-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
Chemical formula C16H13ClN2O
Molecular weight 284.7
Bioavailability 93%
Metabolism Hepatic
Elimination half-life 36-100 hours
Excretion Renal
Pregnancy category D (USA)
C (Aus)
Legal status Schedule IV (International)
Routes of administration Oral, IM, IV, suppository

Diazepam (marketed under brand names Valium®, Seduxen® and Apozepam®)[1] is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative, skeletal muscle relaxant and amnestic properties. This makes it a useful drug for treating anxiety, insomnia, muscle spasms and some forms of epilepsy. It is also used before certain medical procedures (such as endoscopies) to reduce tension and anxiety, and in some surgical procedures to induce amnesia.
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VALIUM® brand of diazepam

INJECTION

For relief of acute anxiety when rapid action is required In acute alcohol withdrawal As a useful adjunct in

• endoscopic procedures • skeletal muscle spasm associated with local pathology, cerebral palsy, athetosis, stiff-man syndrome, tetanus • status epilepticus and severe recurrent convulsive seizures

As premedication in patients undergoing

• surgical procedures • cardioversion

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Before taking diazepam,

* tell your doctor and pharmacist if you are allergic to diazepam, alprazolam (Xanax), chlordiazepoxide (Librium, Librax), clonazepam (Klonopin), clorazepate (Tranxene), estazolam (ProSom), flurazepam (Dalmane), lorazepam (Ativan), oxazepam (Serax), prazepam (Centrax), temazepam (Restoril), triazolam (Halcion), or any other drugs.
* tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially antihistamines; cimetadine (Tagamet); digoxin (Lanoxin); disulfiram (Antabuse); fluoxetine (Prozac); isoniazide (INH, Laniazid, Nydrazid); ketoconazole (Nizoral); levodopa (Larodopa, Sinemet); medications for depression, seizures, pain, Parkinson's disease, asthma, colds, or allergies; metoprolol (Lopressor, Toprol XL); muscle relaxants; oral contraceptives; probenecid (Benemid); propoxyphene (Darvon); propranolol (Inderal); ranitidine (Zantac); rifampin (Rifadin); sedatives; sleeping pills; theophylline (Theo-Dur); tranquilizers; valproic acid (Depakene); and vitamins. These medications may add to the drowsiness caused by diazepam.
* if you use antacids, take diazepam first, then wait 1 hour before taking the antacid.
* tell your doctor if you have or have ever had glaucoma; seizures; or lung, heart, or liver disease.
* tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking diazepam, call your doctor immediately.Diazepam affects chemicals in the brain that may become unbalanced and cause anxiety, seizures, and muscle spasms. • Diazepam is used to relieve diazepam anxiety, nervousness, diazepam and tension associated with anxiety disorders. It is also used to diazepam treat certain types diazepam of seizure disorders and muscle spasms. • Diazepam may also be used for purposes other than diazepam those listed in this medication guide. What should I diazepam discuss with diazepam my healthcare provider before taking diazepam? • Do not take diazepam if you have narrow-angle glaucoma. Diazepam diazepam may worsen this condition. • Before diazepam taking this medication, tell your doctor if you · have kidney disease; · have liver disease; · have diazepam asthma, bronchitis, emphysema, or another respiratory disease; or diazepam
* if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking diazepam.
* you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how this drug affects you.
* remember that alcohol can add to the drowsiness caused by this drug.
* tell your doctor if you use tobacco products. Cigarette smoking may decrease the effectiveness of this drug.




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Extended release formulation. There is a change in most cases that confirm its usefulness. Methods we present an observational prospective naturalistic study there is in the third or panic attacks..

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Do not

Do not take this drug if you are pregnant. Some studies have found that taking this drug may lead to serious birth defects. If this drug is used in late pregnancy it may cause " floppy infant" syndrome.
Do not take this drug if planning to become pregnant. Do not take if you are breast-feeding.
Do not give this drug to anyone under six mounts old and never use on hyperactive or psychotic children. Only use drug in small doses if over sixty with close monitoring.
Do not use if: You had negative reactions to other benzodiazepines, if you have a history of drug dependence, if you have had a stroke, if you have multiple sclerosis, if you have Alzheimer's disease, if you are seriously depressed or if you have other brain disorders.


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Diazepam is an anti anxiety agent ( benzodiazepines. ) Used primarily for short-term relief of mild to moderate anxiety. It may also be used to treat symptoms of acute alcohol withdrawals, to help control epilepsy, or to relieve muscle spasms. Diazepam affects chemicals in the brain that may become unbalanced and cause anxiety, seizures, and muscle spasms. Diazepam is used to relieve anxiety, nervousness, and tension associated with anxiety disorders. It is also used to treat certain types of seizure disorders and muscle spasms. Diazepam may also be used for purposes other than those here. Information: Most Common Medical Uses Diazepam affects chemicals in the brain that may become unbalanced and cause anxiety, seizures, and muscle spasms. Diazepam is used to relieve anxiety, nervousness, and tension associated with anxiety disorders. It is also used to treat certain types of seizure disorders and muscle spasms. Diazepam may also be used for purposes other than those here.
Take diazepam exactly as directed by your doctor. Take each oral dose with a full glass of water. To ensure the correct dose, measure the liquid forms of diazepam with a dose-measuring spoon or cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one. Do not take diazepam more often or in larger doses than is prescribed. Diazepam is habit forming. You can become physically and psychologically dependent on the medication. Do not take more than the prescribed amount of medication or take it for longer than is directed by your doctor. Withdrawal effects may occur if diazepam is stopped suddenly after several weeks of continuous use. Your doctor may recommend a gradual reduction in dose.
Do not take more than the prescribed amount of medication or take it for longer than is directed by your doctor. Withdrawal effects may occur if lorazepam is stopped suddenly after several weeks of continuous use. Your doctor may recommend a gradual reduction in dose.
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